What Are the Best Hybrid Strains In 2021?

Fraser Horton
Fraser Horton
Last Updated on November 24, 2021

Over the years, the cannabis market has become a huge source of a delectable variety of strains that makes it hard to pick just one. Unlike the olden days, today we have an extensive selection of strains and phenotypes, so there’s a perfect strain for everyone, whether for relaxing or medicinal purposes.

This is why hybrids have taken over the cannabis market, each strain producing a specific set of effects. So, if you’re looking for that perfect high that only the best hybrid marijuana strains can give you, here’s a list of the ones which have remained staple hybrids that every “cannaisseur” should try. We’ll review each hybrid in no particular order so you can choose the ideal strain for your wants and needs. Let’s begin!

10 Best Hybrid Strains of Weed (2021 Top List)

1. OG Kush

OG Kush is a classic strain as there’s rarely anyone who hasn’t heard of it. This strain is a balanced hybrid, slightly leaning onto Sativa, that’s been enjoying huge popularity ever since its creation in Florida in the 1990s. Its lineage is somewhat a mystery, with assumptions being that it’s a cross between Chemdawg and Hindu Kush landrace. With THC levels that can vary between 20 and 25%, OG Kush is among the more potent strains on our list.

Flavor and aroma-wise, OG Kush is a true delight in unexpected ways. It has a distinct woodsy and piney aroma with fresh earthy undertones, while the taste has noticeably lemony and citrusy notes and spice.

Being a balanced hybrid, OG Kush produces a mix of effects that offer the best of both worlds – one of the reasons why it’s so well-liked by a vast majority of users. The high starts off as a strong and uplifting euphoria that soon settles into the body and produces body-melting relaxation, sometimes to the point of couch-lock. Therefore, while the feelings of bliss remain in your mind, your body also feels mellowed out to the maximum.

As medical marijuana, OG Kush is commonly used to relieve chronic pain and inflammation. If used for anxiety and depression, lower doses are recommended to avoid achieving the opposite effect (due to its high THC content).

2. White Widow

White Widow is a friendly Sativa-dominant hybrid loved by everyone for its easy-going effects. Its parents are Brazilian Indica and South Indian Sativa landraces, lending it an interesting flavor profile that’s hard to leave any weed connoisseur indifferent.

With an average THC content of about 20%, White Widow will imbibe you with mental and creative energy without overwhelming you. You’ll feel a burst of creativity and stamina enabling you to focus on any task ahead, either simple or complex. The high is euphoric and uplifting, but you’ll feel a mellow buzz within your body, too.

White Widow will lure you with its interesting combination of flavors and aromas, but it’s extremely pungent in characteristic. Initially, you’ll get hit with a whiff of fruity notes, like peach and apple – and soon after, you’ll feel the spiciness underneath, akin to nutmeg and cinnamon. But what makes it so smelly is the ever-present skunky aroma that’s especially noticeable when you smoke it.

Medically, White Widow is great for improving focus in those who are struggling with ADHD, and it’s also great for combating fatigue and low mood.

3. Wedding Cake

Wedding Cake sounds as sweet as its parents – Cherry Pie and Girl Scout Cookies (GSC), and just like them, it packs a big punch, too. With a THC content of up to 27%, smoking this Indica-dominant hybrid is an experience in itself, but the flavor is far from a wedding cake.

Instead, you’ll feel a mix of sweetness and tanginess, with noticeable spicy and earthy undertones. The aroma is sweet, but not pronounced, and there are some understated floral notes.

Wedding Cake creates a euphoric high that’s bordering on the psychedelic. Apart from sharpening your senses, it’ll leave both your body and mind utterly relaxed and happy, like all your worries are vanishing into thin air. The high starts in the head and then it gradually turns into a warm and fuzzy couch-lock.

Medically, this hybrid is excellent for controlling stress levels, calming down the nerves, and lifting up the mood. Wedding Cake is also a popular strain for relieving joint and muscle pain caused by arthritis, sciatica, and fibromyalgia.

Due to its very high THC content, novice users should be wary of consuming too much to avoid experiencing side effects.

4. Jack Herer

Jack Herer, named after the cannabis rights activist and author of The Emperor Wears No Clothes, is a Sativa-dominant hybrid created with the purpose of achieving the perfect balance between a head high and a body high, and for these reasons, it has been popular since its creation in the 1990s.

Jack Herer provides both the mind and the body with an easy-going relaxation without immobilizing you. The high starts with a rush to the head and an instant buzz that after a while goes down to your limbs, relaxing you, while not losing grip on the initial mind-buzz. The result is a blend between being blissfully relaxed and creatively loaded so that you can focus on any task or conversation ahead.

Medically, Jack Herer can be used for treating the symptoms of anxiety and depression, and its focus-boosting Sativa genetics make it effective even for ADHD. Its taste and aroma are citrusy all the way, with notes of lemon, pine, and orange, and there is a faint skunk-like smell due to its lineage.

5. AK-47

AK-47 has an interesting origin; it was created in 1992 in the Netherlands by crossing four different landrace strain varieties – Afghani, Thai, Colombian, and Mexican. The result is an incredibly complex Sativa-dominant hybrid with 20% THC that, unsurprisingly, has won no less than 16 awards, including the High Times Cannabis Cup.

While the aroma of AK-47 is earthy and sour, its taste is delicately sweet and flowery. Its effects are bright and uplifting, creating a long-lasting mental buzz to help you focus while maintaining inner peace.

AK-47 can help you ease your anxiety and unwind. Kicking back while letting your mind float while smoking this strain is a common way of consumption. It can also relieve chronic pain and headaches. However, dry mouth is common with this hybrid so make sure you don’t go overboard.

6. GSC (Girl Scout Cookies)

Girl Scout Cookies (GSC) is a Cannabis Cup award-winning Indica dominant hybrid whose parents are Durban Poison and OG Kush, two extra popular cannabis strains. GSC’s THC content is very impressive, as it goes up to a whopping 28% – so newbies, beware! Despite what its appetizing name suggests, GSC is a potent strain not to be messed with. But that’s what also makes it so desirable.

GSC produces a happy and euphoric high followed by an ultra chill, full-body relaxation (very close to couch-lock), after which you get the munchies as an encore. It’s perfect for when you want to relax and let your worries melt away. That being said, it’s probably not the best for when you need some creative energy, so it’s better to save it for when you need a few hours to yourself.

Its aroma and flavor are just what the name implies – GSC is sweet-smelling, earthy, herby, and slightly minty. It smells even better when burned, as the smokiness really comes forward.

Medical users especially love GSC because it relieves stress and depression, as well as chronic pain, migraine, nausea, and lack of appetite.

7. Gorilla Glue

Gorilla Glue is another multi-award-winning top hybrid strain that’s adored by many 420 enthusiasts, both frequent and casual users alike. This Sativa-dominant hybrid is super potent – it can boast up a high THC content of up to 28%, making it one of the most powerful marijuana strains on the market. Therefore, novice users should avoid it until they build up tolerance, while experienced users should watch their doses as the chances of experiencing side effects are high.

Gorilla Glue, also called Original Glue, is bred from Sour Dubble, Chocolate Diesel, and Chem’s Sister. Its aroma is truly irresistible – you’ll get a strong whiff of coffee and chocolate mixed with piney diesel smell, while its flavor is earthy and sour.

This hybrid definitely hits hard. It produces an intensely relaxing high and a heavy euphoria that leaves you in a couch-lock state, making it perfect for nighttime. You’ll be mellowed out and happy (and might even get the giggles), and you’ll feel all the stress from the week melting away from you.

Medically, Gorilla Glue is often used by patients seeking relief from muscle spasms and chronic pain, however, it’s equally good for insomnia, depression, and loss of appetite. In any case, this strain is powerful and highly likely to give you a cottonmouth, so you’d better prepare a glass of water.

8. Chemdawg

Although its parents are shrouded in mystery, Chemdawg is at the top as one of the most potent strains. While its exact lineage is unknown, we know that it’s more or less a balanced hybrid, slightly leaning towards Sativa, and it boasts a THC content between 15-22%.

Chemdawg has a strong and recognizable chemical, diesel-like aroma, with notes of musk and pine. The flavor is strong and tangy – when smoked, it may not be to everyone’s taste, but an unforgettable one, indeed.

This hybrid produces a cerebral high that heightens the senses, making it desirable for when you need to focus and get those creative juices flowing. It can make you hyper-aware of your surroundings, noticing even the smallest of details, and if you’re in a social setting, prepare for lengthy and enjoyable discussions.

By lifting up your mood, Chemdawg can help with stress, anxiety, and symptoms of depression. However, due to its potency and fast-acting effects, you should be careful with Chemdawg, as you may experience side effects such as anxiety and paranoia, even if you’re an experienced user.

9. Sour Diesel

There probably isn’t a single weed enthusiast in the world that hasn’t heard of Sour Diesel. The popularity of this hybrid has skyrocketed since its creation in the 1990s in California. It’s famous for its fast-acting and long-lasting high that’s the perfect combination of feeling dreamy and energizing. You’ll feel its cerebral effects soon after you inhale it and its vigor will imbue you with mental energy.

Sour Diesel is a Sativa-dominant hybrid with THC levels that can go up to 20%. As its name suggests, its aroma is rich, pungent, and skunky. It’s heavy, sour, and gassy, and it’ll punch your nostrils, but in a good way. Its flavor profile unlocks new depths with the earthy and herbal notes characteristic of a skunk strain and the lemony aftertaste.

Sour Diesel is that strain that will help you defeat fatigue, low appetite, or a migraine that has been bugging you. It’s great for relieving stress and combating low mood, and you’ll notice this the second your mind starts to clear.

10. Blue Dream

Blue Dream has been one of the most popular hybrids on the market for years now. Equally effective for both recreational and medical use, this Sativa-dominant hybrid is well-loved by many “cannaisseurs” precisely because of its versatility. It produces an easy-going high that’ll make you feel creative and energized but peaceful at the same time.

Blue Dream is a cross between Blueberry (an Indica) and Haze (a Sativa). It has a delectable berry scent that upon a closer whiff unravels notes of earthy sandalwood and hints of citrus notes that are faint (but there).

With high THC levels that can range between 17-25%, Blue Dream is very good for wake-and-bake, when you want to set the mood of the day right from the start. It’s also great for a midday pick-me-up when you need a little energy boost. Blue Dream is not your best choice as a bed-time toke, though, but if you’re planning a sociable night out, it’s a wonderful companion.

Medically, Blue Dream is most commonly used to improve the symptoms of depression and anxiety, or any time low mood strikes you. Its mood-boosting effects will make you feel more at ease and will perk you up right away. Blue Dream is also effective for headaches and chronic pain – another reason why it’s widely loved by medical users. All in all, Blue Dream is an all-rounder that you’ll probably love.

What Are Hybrid Cannabis Strains?

Hybrid cannabis strains are a cross between two types of the cannabis plant, namely, Cannabis Indica and Cannabis Sativa. There are hybrids that are balanced, meaning they contain equal parts of Indica and Sativa, or they can be dominant in one strain. There are also hybrids that are created from two or more different Indicas or Sativas – so they can go either way.

Nonetheless, hybrids were created to produce the perfect high. Breeders tend to select the plants that show the most genetic potential and those that have the best cannabinoid and terpene profiles.

Therefore, when growers take one strain that has excellent THC content and alluring aroma and combine it with another strain that has an interesting flavor profile and anti-inflammatory properties, a new strain is created, with an original fusion of effects, flavors, and aromas.

In order to understand hybrids better, we need to look at the differences between Sativas and Indicas first.

Cannabis Sativa vs. Cannabis Indica

Cannabis Sativa is one of the two main types of cannabis. It has long stalks and slender light green fan leaves. It can grow up to 12 feet tall and the buds are sparsely located on the branches.

Pure Sativa strains tend to be naturally high in THC and low in CBD, and for this reason they’re known for producing an energizing high that you’ll predominantly feel in your head, also known as a head high or a cerebral high. Pure Sativa strains are more often used recreationally than medically – and in high doses can cause side effects due to the high THC content.

Cannabis Indica is the complete opposite of Cannabis Sativa. Indica plants are short and bushy with thick, dark green fan leaves. Indicas are also high in THC, but they have more CBD than Sativas, making them more calming and sedating.

The high that pure Indicas produce is felt all throughout the body, also called a body high. You usually feel your muscles relaxing and the tension leaving your body. Some Indicas’ sedating effect is so strong that it’ll make you feel like you’re unable to move (but in a good way), an effect also known as a couch-lock. Due to the higher CBD content and their relaxing properties, Indica strains are often used as medical marijuana.

With that being said, hybrids are a mixture of the genetics of both parents, effect-wise and appearance-wise. Knowing the lineage of a hybrid can tell you more about the effects it’s capable of producing. Some hybrids can start you off with a refreshing head high that’ll soon turn into a nice and relaxing body-high, while others can feel like a shot of espresso or a body-melting massage. It all depends on its genetics.


What are the medical benefits of hybrid marijuana strains?

Being a cross of different strains, hybrid weed strains offer many medical benefits. While typically pure Indica strains are considered to be more suitable for medical use, and pure Sativa strains are more sought after for their recreational effects, with hybrids, there are no rules.

Hybrids are literally the best of both worlds, but the most important thing to remember when choosing a hybrid strain is to take into account its entire chemical profile, not just whether it’s a balanced, or a Sativa/Indica dominant strain.

That being said, many hybrids are very effective for easing the symptoms of anxiety and depression and lessening the burden of everyday stress. Hybrids can also help with chronic pain relief and reduce inflammation of the joints and muscle aches. Nausea and appetite loss can also be treated with hybrids, especially those with higher THC levels, while some Sativa-dominant hybrids can even be good for improving focus and fighting mental and physical fatigue.

What is the strongest hybrid strain?

Unlike the cannabis strains of the past whose cannabinoid content was significantly low, today’s hybrids have been purposefully bred to be as strong and potent as possible. That not only entails having a solid cannabinoid content, but terpene content as well since terpenes work synergistically with the cannabinoids. However, when talking about the potency of a strain, we typically refer to the strains’ cannabinoid content, more specifically, its THC levels.

Normally, a hybrid will have a set range of THC levels that it can reach. What end of the range a certain hybrid reaches will depend on different variables during the growing season that may affect the outcome when harvest comes. Nonetheless, some hybrids are capable of producing higher THC levels than others, and that’s what makes them so powerful.

The most powerful hybrids on the market usually test at around 25% THC or more, making them stand out from the rest. Of course, one shouldn’t forget the terpenes, because they also affect the high.

Is hybrid an upper or a downer?

Some may say that the best Sativas offer the best cerebral high that energizes you, while the best Indicas produce the best couch-lock effect that sedates you – but hybrids beg to differ.

Hybrid strains can act as both an upper and a downer, depending on not only which strain is dominant, but also the overall ratio of the cannabinoids and terpenes.

For example, many calming hybrids often contain significant amounts of linalool, a terpene with sedating properties (also found in lavender) that can mitigate the intensity of THC to some extent.

Similarly, limonene is another terpene with a citrusy scent that has a bright and energetic effect and can compliment the intensity of THC, making you feel active and buzzed.

Some hybrids contain a higher percentage CBD (cannabidiol), making them more calming, or they may contain other cannabinoids, such as CBG (cannabigerol), which is another calming cannabinoid with anti-inflammatory effects.

Therefore, it’s best to talk to the budtender when you go to a dispensary and explain what exactly you’re looking for (so that you can choose the best hybrid for your needs).

Final Thoughts

Compared to 50 years ago, weed connoisseurs today have it easy – the variety of fragrant and effective weed strains is overwhelming, and it’s all thanks to hybrids and the elevated breeding techniques. Hybrids have become the dominant strains on the market because of their high cannabinoid content, interesting flavor and aroma profiles, and a blend of specific effects that are equally beneficial for both recreational and medical users. So, hybrids being as awesome as they are, you definitely can’t go wrong with choosing any of the ones we included in our list!


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